I too had one of these similar frustrating nights last night with SGP. No matter what, I could not get the target centered. I was going after NGC 457.
Lenovo X220 Tablet / i7, Windows 8.1
SGP 2.4.3.25
iEQ45 Pro w/iOptron ASCOM
Everything had been working just fine over several prior nights and the mount hadn’t been moved since the last successful imaging session. I did insert a new spacer flange (1.25") from MoonLite on my focuser to help reduce the amount the focus tube extends to get prime focus with my DSLR. I rather doubt that had much to do with this, but wanted to mention it just because it was a ‘change’ in equipment.
I did re-do the 3-star alignment, just to be sure the mount was properly aligned and when I checked my guiding with PHD (forced a re-calibration) it was guiding very well. Didn’t check the drift-alignment, but given the good guiding graph, didn’t seem necessary.
I’ve posted one of my SGP logs from last nights attempts here: https://ronbokpublic.blob.core.windows.net/sgp/sg_logfile_20160211183828.zip
I finally gave up, and decided to bring the mount head inside to warm up since its been out there for several weeks and the temps for this weekend are going down below zero. I’ll try again once the sky’s clear and temps get near freezing again. Any thoughts on why this would occur all of a sudden?