I don’t know how your cables plug into the Eagle3, but any logic to following … odd that it looks like your filter wheel and autoguider remained connected. Just your Flat box, camera and NightCrawler were out.
I had a similar problem with my NightCrawler losing connection - as it turned out it was only near meridian limits, and was a bad cable. When it lost connection, it would knock out my autoguider for some reason. My little NUC has two separate USB banks (front and back), and the NC and AutoGuider were plugged into same bank. I swapped the cable to the NightCrawler, and fixed it - bizzare.
Also, out of curiosity, why did your telescope try to meridian flip in the middle of imaging the Horsehead - but then telescope reports its pointing EAST when you resume imaging the Horsehead after your ABORT?
1st error
[12/15/20 00:17:02.787][DEBUG][CP Update Thread][SQ;] ASCOM Focuser: Error in GetCurrentPosition. : The port is closed.
… But 14 seconds later your telescope tried to flip …
[12/15/20 00:17:16.192][DEBUG][Sequence Thread][SQ;] Meridian Flip needed, Hour Angle >= Degrees Past To Flip: 4.4813827554056 >= 4.25
[12/15/20 00:17:16.192][DEBUG][Sequence Thread][SQ;] Running blocking meridian flip…
[12/15/20 00:17:16.192][DEBUG][Main Thread][SQ;] Adding sequence level notification: Running automatic pier flip…
[12/15/20 00:17:16.194][DEBUG][Sequence Thread][SQ;] Sending Notification: Status - Running automatic pier flip…
[12/15/20 00:17:16.301][DEBUG][Pier Flip Thread][SQ;MF;] Meridian Flip: Starting Meridian Flip Procedure
[12/15/20 00:17:16.302][DEBUG][Pier Flip Thread][SQ;MF;] Meridian Flip: Skipping Solve
[12/15/20 00:17:16.304][DEBUG][Pier Flip Thread][SQ;MF;] Meridian Flip: Stopping the Auto Guider
[12/15/20 00:17:16.305][DEBUG][Pier Flip Thread][SQ;MF;] Meridian Flip: Sending Telescope command to execute meridian flip
[12/15/20 00:17:16.496][DEBUG][Telescope Thread][SQ;MF;] ASCOM Telescope: Pier side is West
[12/15/20 00:17:16.496][DEBUG][Telescope Thread][SQ;MF;] ASCOM Telescope: attempting pier flip using slew
…
[12/15/20 00:17:17.356][INFO][Telescope Thread][SQ;MF;] Telescope: Using “OFFSET” sync option, updating slew cooridnates with offsets:
[12/15/20 00:17:17.356][INFO][Telescope Thread][SQ;MF;] RA: 0.378587786382307 hours
[12/15/20 00:17:17.356][INFO][Telescope Thread][SQ;MF;] DEC: -2.40640973578573 degrees
[12/15/20 00:17:17.356][DEBUG][Telescope Thread][SQ;MF;] Telescope: Slewing to J2000 RA: 5.67881679573461 (05h40m43.74s) Dec: -2.40640973578573 (-02°24’23.08")
…
[12/15/20 00:17:51.765][DEBUG][Telescope Thread][SQ;MF;] Telescope thread is IDLE…
[12/15/20 00:17:51.810][DEBUG][Pier Flip Thread][SQ;MF;] Meridian Flip: Telescope command to meridian flip has completed
[12/15/20 00:17:51.811][DEBUG][Pier Flip Thread][SQ;MF;] Adjusting rotator for flip…
[12/15/20 00:17:51.811][DEBUG][Pier Flip Thread][SQ;MF;] Sequence is running, querying running target for target rotation info…
[12/15/20 00:17:51.811][DEBUG][Pier Flip Thread][SQ;MF;] Rotator is connected, but SGPro thinks it should not adjust camera angle…
[12/15/20 00:17:51.811][DEBUG][Pier Flip Thread][SQ;MF;] Meridian Flip: Telescope has performed meridian flip
[12/15/20 00:17:51.811][DEBUG][Pier Flip Thread][SQ;MF;] Meridian Flip: Flipping Auto Guider calibration data
[12/15/20 00:17:51.812][DEBUG][Pier Flip Thread][SQ;MF;] Autoguider (Direct Mount Guider) successfully flipped calibration data
[12/15/20 00:17:51.812][DEBUG][Pier Flip Thread][SQ;MF;] Meridian Flip: Skipping auto center
[12/15/20 00:17:51.812][DEBUG][Pier Flip Thread][SQ;MF;] Meridian Flip: Auto guider resuming
[12/15/20 00:17:51.812][DEBUG][Pier Flip Thread][SQ;MF;] Meridian Flip: Auto guider resuming has completed
…
[12/15/20 00:17:58.735][DEBUG][Sequence Thread][SQ;] Meridian Flip successful
[12/15/20 00:17:58.739][DEBUG][Main Thread][SQ;] Adding sequence level notification: Automatic pier flip was successful…
[12/15/20 00:17:58.742][DEBUG][Pier Flip Thread][SQ;] Meridian Flip: Procedure complete
[12/15/20 00:17:58.742][DEBUG][Sequence Thread][SQ;] Sending Notification: StatusAutoFlip - Automatic pier flip was successful…
[12/15/20 00:17:58.742][DEBUG][Sequence Thread][SQ;] EventMarker(3) - t:Horsehead (2); e:1; f:19; o:
[12/15/20 00:17:58.742][DEBUG][Sequence Thread][SQ;] Waiting for AF to complete…
[12/15/20 00:17:58.751][DEBUG][Camera Thread][SQ;] SGM_FOCUSER_AUTO_FOCUS message received…
[12/15/20 00:17:58.751][DEBUG][Camera Thread][SQ;AF;] Alnitak Flat Box - Getting shutter status
[12/15/20 00:17:58.752][DEBUG][Camera Thread][SQ;AF;] Caught exception in AlnitakFlatBox:SendSerial: The port is closed.
[12/15/20 00:17:58.752][DEBUG][Camera Thread][SQ;AF;] Caught exception in AlnitakFlatBox:SendSerial: The port is closed.
[12/15/20 00:17:58.753][DEBUG][Camera Thread][SQ;AF;] Caught exception in AlnitakFlatBox:SendSerial: The port is closed.
[12/15/20 00:17:58.753][DEBUG][Camera Thread][SQ;AF;] Invalid return from serial. Val is ()
…